I use multiple physical machines for Security related work specially for testing and TI work. I want to reduce the number of systems from 6 to about 3 or 4. I will be replacing one VMWare host that runs Win 10 Pro with Qubes OS. This means I can use the same system for Red/Blue work That's two down. If it's stable enough, it could become a Dev machine as well.
Anyone doing Security related work should check it out. it makes for a great system to use in any lab/test environment. Specially if you want to deal with Malware on a regular basis, this is the best OS to use today.
I have always wanted to use VPN and bounce at OS level. This OS is the answer. You do need to use a physical machine or USB boot as it comes with it's own Xen hypervisor and doing anything else (VM) is just wasting your time.
You can get the OS here https://www.qubes-os.org/